4-Nitrobenzoic acid
4-Nitrobenzoic acid
CAS: 62-23-7
Molecular Formula: C7H5NO4
4-Nitrobenzoic acid - Names and Identifiers
| Name | 4-Nitrobenzoic acid |
| Synonyms | 4-nitrodracylicacid 4-Nitrobenzoic acid Benzoicacid,4-nitro- acide4-nitrobenzoique Benzoic acid, p-nitro- Para nitro Benzoic acid kyselinap-nitrobenzoova PARA NITRO-BENZOIC ACID Kyselina p-nitrobenzoova Benzocaine EP Impurity E kyselinap-nitrobenzoova(czech) |
| CAS | 62-23-7 |
| EINECS | 200-526-2 |
| InChI | InChI=1/C7H5NO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4H,(H,9,10)/p-1 |
4-Nitrobenzoic acid - Physico-chemical Properties
| Molecular Formula | C7H5NO4 |
| Molar Mass | 167.12 |
| Density | 1.61 |
| Melting Point | 239-242℃ |
| Boling Point | 359.1°C at 760 mmHg |
| Flash Point | 166.5°C |
| Water Solubility | <0.1 g/100 mL at 26℃ |
| Vapor Presure | 8.78E-06mmHg at 25°C |
| Appearance | White crystal |
| Storage Condition | Room Temprature |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.6280 (estimate) |
| MDL | MFCD00007352 |
| Physical and Chemical Properties | trait white or light yellow medium crystalline, odorless. |
| Use | It is used as a pharmaceutical intermediate and a raw material for the production of dyes. |
4-Nitrobenzoic acid - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed |
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
4-Nitrobenzoic acid - Upstream Downstream Industry
| Raw Materials | Sodium dichromate dihydrate 4-Nitrotoluene Chloramphenicol 2-Amino-1-(4-nitrophenyl)-1,3-propanediol |
| Downstream Products | 4-Aminobenzamide 4-Aminobenzoic acid Procaine hydrochloride |
4-Nitrobenzoic acid - Nature
Open Data Verified Data
yellow-white crystals. The relative density was 1. 610. The melting point was 239-241 °c. Flammable. Soluble in ethanol, ether, chloroform, acetone, boiling water, benzene-soluble, carbon disulfide, insoluble in petroleum ether. Can sublimate.
Last Update：2025-06-10 22:55:16
4-Nitrobenzoic acid - Preparation Method
Open Data Verified Data
p-nitrobenzoic acid is produced by oxidizing p-nitrotoluene with sodium dichromate at 55 ° C. In the presence of sulfuric acid. The reaction solution was filtered, centrifuged and dehydrated, washed with water and dried to obtain a finished product.
Last Update：2022-01-01 10:50:45
4-Nitrobenzoic acid - Introduction
Standard value uncertainty unit melting point (c) f = 1,△ t = 0 239 · 58 0 · 05 melting point (c) f = 1,△ t = 0 capillary melting point (full melting point)(?C) 0 • 20?C/min 240 · 57 0 · 11 capillary melting point (full melting point)(?C) 0 • 20?C/min capillary melting point (full melting point)(?C) 1 • 0?C/min 241 · 33 0 · 20 capillary melting point (full melting point)(?C) 1 • 0?C/min
Last Update：2022-10-16 17:27:15
4-Nitrobenzoic acid - Application
Open Data Verified Data
for the preparation of various anesthetics (procaine hydrochloride) and dye intermediates, and can be prepared filter agent.
Last Update：2025-08-19 16:24:40
4-Nitrobenzoic acid - Safety
Open Data Verified Data
- This product is toxic. It is irritating to the skin. The mouse LD50o of its sodium salt is 10 mg/kg. Production equipment should be sealed to prevent leakage. The operator should wear protective gear.
- It is packed in an iron drum, a fiberboard drum or a hemp bag lined with a plastic bag. 20kg or 40kg net weight per barrel (bag). Store in a cool, ventilated, dry place, heat, sunscreen. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:50:46
4-Nitrobenzoic acid - Nature
| melting point | 237-240 °C(lit.) |
| boiling point | 295.67°C (rough estimate) |
| density | 1.61 |
| refractive index | 1.6280 (estimate) |
| flash point | 237 °C |
| storage conditions | Store below 30°C. |
| solubility | 0.42g/l |
| morphology | Crystalline Powder |
| acidity coefficient (pKa) | 3.41(at 25℃) |
| color | Light yellow |
| PH value | 3.1 (0.42g/l, H2O, 20℃)(saturated solution) |
| water solubility | <0.1 g/100 mL at 26 °C |
| Merck | 14,6589 |
| Solvent | Ethanol |
| Specific Activity | 50-60 mCi/mmol |
| Concentration | 0.1 mCi/ml |
| BRN | 973593 |
| stability | Stable. Combustible. Incompatible with strong oxidizing agents, cyanides, strong bases. |
| InChIKey | OTLNPYWUJOZPPA-UHFFFAOYSA-N |
| NIST chemical information | Benzoic acid, 4-nitro-(62-23-7) |
| EPA chemical information | p-Nitrobenzoic acid (62-23-7) |
Last Update：2024-04-10 22:29:15
4-Nitrobenzoic acid - MSDS
| SigmaAldrich | English |
| ACROS | English |
| ALFA | Chinese |
| ALFA | English |
Last Update：2024-04-10 22:29:15
4-Nitrobenzoic acid - Security information
| dangerous goods mark | Xn |
| hazard category code | 22-41-36 |
| safety instructions | 26-39-24/25 |
| WGK Germany | 1 |
| RTECS number | DH5075000 |
| TSCA | Yes |
| customs code | 29163900 |
| toxic substance data | 62-23-7(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1960 mg/kg |
Last Update：2024-04-10 22:29:15
4-Nitrobenzoic acid - Uses and synthesis methods
chemical properties
yellow-white crystals. Soluble in ethanol, ether, chloroform, acetone, boiling water, slightly soluble in benzene, carbon disulfide, insoluble in petroleum ether.
use
1. Used as a chemical reagent
2. Used as a pharmaceutical intermediate and a raw material for the production of dyes
3. this product is an intermediate for organic synthesis of medicines, dyes, veterinary drugs, photosensitive materials, etc. Used for the production of procaine hydrochloride, procainamide hydrochloride, p-aminomethylbenzoic acid, folic acid, benzocaine, anti-cough, cephalosporin V, p-aminobenzoylglutamic acid, Benil, and the production of reactive brilliant red M-8B, reactive red-violet X-2R, filter, color film color former, metal surface rust remover, sunscreen, etc.
4. It is used to make anesthetic procaine hydrochloride and dye intermediates, as well as filter. It can also be used in the production of photosensitive materials, the production of photosensitive materials and the electric paste in capacitors.
5. It is used to synthesize procaine, procainamide, p-aminobenzoic acid, folic acid, etc. It is also widely used to synthesize pesticides and fuels.
6. check alkaloids and calibrate standard alkali solution.
production method
It is obtained by oxidation of p-nitrotoluene. The oxidant can be sodium dichromate, air, manganese ore powder, nitric acid, etc. Using p-nitrotoluene as raw material, in the presence of sulfuric acid, the oxidation reaction is carried out with sodium dichromate at 55 ℃ to generate p-nitrobenzoic acid. The reaction liquid is filtered, centrifuged and dehydrated, washed and dried to obtain the finished product. In addition, it is easy to oxidize with nitric acid to obtain p-nitrobenzoic acid by using 1-p-nitrophenyl -2-amino -1, 3-propanediol in the production of chloramphenicol.
Last Update：2024-04-09 21:04:16
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
CAS: 62-23-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
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Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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Product Name: 4-Nitrobenzoic acid Request for quotationCAS: 62-23-7
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
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Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Product Name: 4-Nitrobenzoic acid Request for quotation
CAS: 62-23-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
CAS: 62-23-7
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Spot supply
Product Name: 4-Nitrobenzoic acid Request for quotationCAS: 62-23-7
Tel: +86-17505207175
Email: 3787852685@qq.com
Mobile: +86-17505207175
QQ: 3787852685
Wechat: chemical6666
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Spot supply
Product Name: 4-Nitrobenzoic acid Request for quotationCAS: 62-23-7
Tel: +86-13776910623
Email: r@reformchem.com
Mobile: +86-13776910623
QQ: 3785839865
Wechat: chemical6666
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Spot supply
Product Name: 4-Nitrobenzoic acid Request for quotationCAS: 62-23-7
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Spot supply
Product Name: 4-Nitrobenzoic acid Request for quotationCAS: 62-23-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Spot supply
Product Name: 4-Nitrobenzoic acid Visit Supplier Webpage Request for quotationCAS: 62-23-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
Multiple SpecificationsSpot supply
Product Name: 4-Nitrobenzoic acid Visit Supplier Webpage Request for quotationCAS: 62-23-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Descriptions:
For the preparation of anesthetic procaine hydrochloride and dye intermediates, can also be prepared filter agent. For the production of procaine hydrochloride, procainamide hydrochloride, aminomethyl More
View History
Raw Materials for 4-Nitrobenzoic acid
Downstream Products for 4-Nitrobenzoic acid